Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

V, Panasenkava; J, Garreau; H, Guyodo; F, Diab; A, Mahieux; W, Carré; Y, Verres; E, Jullion; S, Odent; C, Dubourg; P, Rollier; L, Dubos; V, Ribes; A, Camus; Tayrac M, de; V, Dupé

doi:10.1101/2025.05.20.654466

Public

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

Shared by NobleBlocks on May 21, 2025 • 12:00 AM UTC

Authors:

Panasenkava V

Garreau J

Guyodo H

Abstract

<h4>SUMMARY</h4> The early patterning of the anterior neuroectoderm constitutes a fundamental blueprint for human brain development, orchestrated by multiple signaling pathways. Among them, Sonic Hedgehog (SHH) plays a key influence. However, the transcriptional programs it engages remain poorly def...

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