Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.

Marchi, Francisco; M Shastri, Vivek; J Marrero, Richard; H K Nguyen, Nam; Öttl, Antonella; Schade, Ann-Kathrin; Landwehr, Marieke; Krali, Olga; Nordlund, Jessica; Ghavami, Matin; Sckaff, Fernando; K Mansinghka, Vikash; Cao, Xueyuan; Slayton, William; Starostik, Petr; R Cogle, Christopher; C Ribeiro, Raul; E Rubnitz, Jeffrey; Klco, Jeffery; Elsayed, Abdelrahman; S Gamis, Alan; J Triche, Timothy; Ries, Rhonda; Anders Kolb, E; Aplenc, Richard; Alonzo, Todd; Pounds, Stanley; Meshinchi, Soheil; K Lamba, Jatinder

doi:10.1038/s41467-025-62005-4

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Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.

Shared by NobleBlocks on Jul 29, 2025 • 12:00 AM UTC

Authors:

Francisco Marchi

Vivek M Shastri

Richard J Marrero

Abstract

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe the Acute Leukemia Methylome Atlas, which includes r...

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