Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity

Wharton, Sean; Lingvay, Ildiko; Bogdański, Paweł; Vale, Ruben; Jacob, Stephan; Karlsson, Tobias; Shaji, Chaithra; Rubino, Domenica; Timothy Garvey, W.

doi:10.1056/nejmoa2500969

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Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity

Published in New England Journal of Medicine • Sep 17, 2025

Authors:

Sean Wharton

Ildiko Lingvay

Paweł Bogdański

Abstract

BACKGROUND: Oral semaglutide at a dose of 25 mg may provide an alternative treatment option to injectable semaglutide (2.4 mg) and higher-dose oral semaglutide (50 mg) for persons with overweight or obesity. METHODS: In a 71-week, double-blind, randomized, placebo-controlled trial conducted at 22 si...

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Subject

Semaglutide

Medicine

Overweight

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