Activating mutations in CTNNB1 in aldosterone producing adenomas.

T, Åkerström; R, Maharjan; Willenberg H, Sven; K, Cupisti; J, Ip; A, Moser; P, Stålberg; B, Robinson; Iwen K, Alexander; H, Dralle; MK, Walz; H, Lehnert; S, Sidhu; C, Gomez-Sanchez; P, Hellman; P, Björklund

doi:10.1038/srep19546

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Activating mutations in CTNNB1 in aldosterone producing adenomas.

Published in Scientific reports • Jan 27, 2016

Authors:

Åkerström T

Maharjan R

Sven Willenberg H

Abstract

Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5-10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically correctable form of the disease. The WNT signaling ...

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