Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

KONIECZNY, ANDREJ; Safer, B

doi:10.1016/s0021-9258(18)32875-8

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Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

Shared by NobleBlocks on Mar 1, 1983 • 12:00 AM UTC

Authors:

ANDREJ KONIECZNY

B Safer

Abstract

AM, = 390,000 complex of eukaryotic initiation factor 2 (eIF-2; 3 subunits, M, = 38, 52, and 55 X lo3) and a factor required for catalytic recycling of eIF-2 (eIF-2B; 5 subunits, M, = 26, 39, 58,67, and 82 X lo3) has been purified from rabbit reticulocyte lysate.The eIF-2 eIF-2B complex can be disso...

Subject

Reticulocyte

GTP'

Initiation factor

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