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Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training

Published in American Journal of Physiology-Heart and Circulatory Physiology • Nov 1, 2002
Authors:
Motoyuki Iemitsu
,
Takashi Miyauchi
,
Seiji Maeda

Abstract

Peroxisome proliferator-activated receptor (PPAR)-α, a transcriptional activator, regulates genes of fatty acid (FA) metabolic enzymes. To study the contribution of PPAR-α to exercise training-induced improvement of FA metabolic capacity in the aged heart, we investigated whether PPAR-α signaling an...

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