Texas Instruments (Germany)

A quantitative yield analysis of a latch-type voltage sense amplifier with a high-impedance differential input stage is presented. It investigates the impact of supply voltage, input DC level, transistor sizing, and temperature on the input offset voltage. The input DC level turns out to be most significant. Also, an analytical expression for the sensing delay is derived which shows low sensitivity on the input DC bias voltage. A figure of merit indicates that an input dc level of 0.7 V/sub DD/ is optimal regarding speed and yield. Experimental results in 130-nm CMOS technology confirm that the yield can be significantly improved by lowering the input DC voltage to about 70% of the supply voltage. Thereby, the offset standard deviation decreases from 19 to 8.5 mV without affecting the delay.

BACKGROUND: This study compares the accuracy of cerebral monitoring systems in detecting cerebral ischemia during carotid endarterectomy. METHODS: The authors compared transcranial Doppler sonography (TCD), near-infrared spectroscopy (NIRS), stump pressure (SP) measurement, and somatosensory evoked potentials (SEP) in 48 patients undergoing carotid surgery during regional anesthesia. Cerebral ischemia was assumed when neurologic deterioration occurred. During clamping, the minimum mean middle cerebral artery velocity (TCD(min)), its percentage change (TCD%), the minimum regional saturation of oxygen (NIRS(min)), its percentage change (NIRS%), the mean SP, and the changes of SEP amplitude were recorded. To analyze the corresponding sensitivity and specificity of each parameter, the authors performed receiver operating characteristic analysis. RESULTS: Neurologic deterioration occurred in 12 patients. SP and NIRS were successfully performed in all patients. TCD monitoring was not possible in 10 (21%); SEP was not possible in 2 patients (4%). All parameters provided the ability to distinguish between ischemic and nonischemic patients. TCD% and NIRS% showed significantly better discrimination than TCD(min) and NIRS(min) (P < 0.05). The highest area under the curve (AUC) was found for TCD% (AUC = 0.973), but there was no significant difference compared with NIRS% (AUC = 0.905) and SP (AUC = 0.925). The lowest AUC was found for SEP (AUC = 0.749), which was significantly lower than that for TCD%, NIRS%, and SP. CONCLUSIONS: TCD%, NIRS%, and SP measurement provide similar accuracy for the detection of cerebral ischemia during carotid surgery. Lower accuracy was found for SEP monitoring. Because of the high rate of technical difficulties (21%), TCD monitoring was the least practical of the investigated monitoring devices.

Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg(2+)-/Mn(2+)-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.

This paper proposes a power management architecture that utilizes both supercapacitor cells and a lithium battery as energy storages for a photovoltaic (PV)-based wireless sensor network. The supercapacitor guarantees a longer lifetime in terms of charge cycles and has a large range of operating temperatures, but has the drawback of having low energy density and high cost. The lithium battery has higher energy density but requires an accurate charge profile to increase its lifetime, feature that cannot be easily obtained supplying the wireless node with a fluctuating source as the PV one. Combining the two storages is possible to obtain good compromise in terms of energy density. A statistic analysis is used for sizing the storages and experimental results with a 5-W PV energy source are reported.

A novel CMOS integrated circuit for a batteryless transponder system is presented. Batteryless transponders require contactless transmission of both the information and power between a mobile data carrier and a stationary or handheld reader unit. The operating principle of this system gives a superior performance in reading distance due to separation of the powering and data transmission phases-compared to systems with continuous powering and damping modulation. This paper describes the function of the transponder IC and the circuit design techniques used for the various building blocks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

The use of groundwater as a carrier of thermal energy is an important source of sustainable heating and cooling. However, the effects of thermal use on geochemical and biological aquifer characteristics are poorly understood. Here, we have assessed the impacts of heat discharge on an uncontaminated, shallow aquifer by monitoring the hydrogeochemical, bacterial and faunal parameters at an active thermal discharge facility. The observed variability between wells was considerable. Yet, no significant temperature impacts on bacterial or faunal abundance and on bacterial productivity were observed. Also, we did not observe an improved survival or growth of coliforms with temperature. In contrast, the diversity of bacterial terminal restriction fragment (T-RF) length polymorphism fingerprints and faunal populations was either positively or negatively affected by temperature, respectively, and the abundance of selected T-RFs was clearly temperature dependent. Canonical correspondence analysis indicated that both the impact of temperature and of surface water from a nearby river, were important drivers of aquifer biotic variability. These results demonstrate that aquifer thermal energy discharge can affect aquifer bacteria and fauna, while at the same time controlling only a minor part of the total seasonal and spatial variability and therefore posing no likely threat to ecosystem functioning and drinking water protection in uncontaminated, shallow aquifers.

This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated

This paper presents a fully autonomous, adaptive pulsed synchronous charge extractor (PSCE) circuit optimized for piezoelectric harvesters (PEHs) which have a wide output voltage range 1.3-20 V. The PSCE chip fabricated in a 0.35 μm CMOS process is supplied exclusively by the buffer capacitor where the harvested energy is stored in. Due to the low power consumption, the chip can handle a minimum PEH output power of 5.7 μW. The system performs a startup from an uncharged buffer capacitor and operates in the adaptive mode at storage buffer voltages from 1.4 V to 5 V. By reducing the series resistance losses, the implementation of an improved switching technique increases the extracted power by up to 20% compared to the formerly presented Synchronous Electric Charge Extraction (SECE) technique and enables the chip efficiency to reach values of up to 85%. Compared to a low-voltage-drop passive full-wave rectifier, the PSCE chip increases the extracted power to 123% when the PEH is driven at resonance and to 206% at off-resonance.

This paper presents a 65nm sub-Vt SoC featuring a microcontroller core and custom 128Kb SRAM functional in sub-threshold, powered by a switched capacitor DC-DC converter that delivers variable load voltages from 0.3V to 0.6V.

This paper presents a CMOS imager with a column-parallel ADC architecture based on a multiple-ramp single-slope (MRSS) ADC. Like the well-known column-level single-slope ADC, an MRSS ADC uses a very simple analog column circuit, which mainly consists of an analog comparator and some switches. A prototype imager using the MRSS ADC architecture was realized in a 0.25 CMOS process. Measurements demonstrate that the conversion speed of an MRSS ADC is 3.3 higher than a single-slope ADC while dissipating only 16% more power. Furthermore, the MRSS ADC can be easily adapted to exhibit a companding characteristic, which exploits the amplitude-dependent nature of the photon shot noise present in imager signals. Measurements show that the resulting multiple-ramp multiple-slope ADC is 25% faster than an MRSS ADC while dissipating the same amount of power.

Piezoelectric harvesters are capable of generating energy out of ambient vibrations. Dedicated interface circuits can significantly increase the harvesting capabilities compared with passive rectifiers. This paper presents an autonomous piezoelectric energy harvesting system in a 0.35-μm CMOS process. The implemented interface is based on the parallel-SSHI technique and can harvest from periodic and shock excitations. Regular operation is enabled for input voltages as low as 670 mV. It extracts up to 6.81 times more power compared with an ideal full-bridge rectifier depending on the generator characteristics and excitation conditions. The device is capable of cold startup and provides a stable output voltage for powering an application.

We present an ultra low power (200 nA current consumption) reverse bandgap voltage reference operational from supply voltages down to 0.75 V. The reference is a part of microprocessor system on chip implemented in a digital 130 nm CMOS process and has a total area of 0.07 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The reference accuracy is ± 2.5% (5 sigma) over a temperature range of - 20 to 85°C without trimming. With trimming ± 0.5% accuracy is achieved.

Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations, and while the modification has been linked to several diseases, including rheumatoid arthritis (RA) and cancer, its physiological or pathophysiological roles remain largely unclear. In part, this is owing to limitations in available methodology to robustly enrich, detect, and localize the modification. As a result, only a few citrullination sites have been identified on human proteins with high confidence. In this study, we mined data from mass-spectrometry-based deep proteomic profiling of 30 human tissues to identify citrullination sites on endogenous proteins. Database searching of ∼70 million tandem mass spectra yielded ∼13,000 candidate spectra, which were further triaged by spectrum quality metrics and the detection of the specific neutral loss of isocyanic acid from citrullinated peptides to reduce false positives. Because citrullination is easily confused with deamidation, we synthetized ∼2,200 citrullinated and 1,300 deamidated peptides to build a library of reference spectra. This led to the validation of 375 citrullination sites on 209 human proteins. Further analysis showed that >80% of the identified modifications sites were new, and for 56% of the proteins, citrullination was detected for the first time. Sequence motif analysis revealed a strong preference for Asp and Gly, residues around the citrullination site. Interestingly, while the modification was detected in 26 human tissues with the highest levels found in the brain and lung, citrullination levels did not correlate well with protein expression of the PAD enzymes. Even though the current work represents the largest survey of protein citrullination to date, the modification was mostly detected on high abundant proteins, arguing that the development of specific enrichment methods would be required in order to study the full extent of cellular protein citrullination.

A continuous-rate clock and data recovery (CDR) circuit that operates from 12.5 Mb/s to 2.7 Gb/s is described. The circuit automatically detects a change in input data rate, acquires the new frequency, and reports the data rate to the user without the need for an external reference clock or any programming. At 2.5Gb/s, it achieves an acquisition time of 1 ms. In tracking mode, it uses a dual DLL/PLL to provide superior jitter performance compared to a standard second-order loop. At the OC48 data rate, it achieves a jitter transfer bandwidth of 500 kHz and a jitter tolerance bandwidth of 3 MHz. It is on a 0.35-/spl mu/m double-poly, triple-metal (DPTM) BiCMOS process, dissipates 235 mA from a 3.3-V supply, and occupies 9 mm/sup 2/. It is in a compact 5/spl times/5 mm/sup 2/ LFCSP package.

In this paper, we report on the bias oscillation of GaN-based Gunn diodes realized on a n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -GaN substrate. Different contact materials, ambient gases, and pulsewidths were used and compared with regard to device stability. A wide negative- differential-resistance (NDR) region was measured for electrical- field values E larger than a threshold field Eth of 150 kV/cm. Electrical fields much higher than the threshold value did not lead to any electromigration effects or discharging problems from the contacts. The drift velocity derived from the current-voltage characteristics, diode geometry, and doping concentration in the active layer was estimated to be 1.9 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> cm/s. Bias oscillations were obtained for the GaN Gunn diodes in the presence of a series inductance.

This paper presents two integrated magnetic sensor ICs for isolated current measurement that have a fluxgate magnetometer co-integrated along with circuitry on a die. The integrated fluxgate has a sensitivity of 250 V/T and a 500 ksps readout circuit and requires only 5.4 mW for fluxgate excitation, which is 20x more power-efficient than the state of the art. The fluxgate magnetometer was used to realize the first fully integrated sensor IC for closed-loop current sensing. It achieves a dynamic range of 112 dB and a nonlinearity below 0.03%. A second realization provides a precision magnetic sensor IC that can be used for open-loop and differential-field current sensing. It features a sensor gain variation of 0.04% (1-sigma), a nonlinearity below 0.2%, a bandwidth of 47 kHz, and a dynamic range of 100 dB.

-overexpressing plants. This shows that GSTU4 is not directly involved in camalexin biosynthesis but rather plays a role in a competing mechanism.

This paper proposes a multipath multisensor architecture for CMOS magnetic sensors, which effectively extends their bandwidth without compromising either their offset or resolution. Two designs utilizing the proposed architecture were fabricated in a 0.18-μm standard CMOS process. In the first, the combination of spinning-current Hall sensors and nonspun Hall sensors achieves an offset of 40 μT and a resolution of 272 μT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> in a bandwidth of 400 kHz, which is 40 times more than previous low-offset CMOS Hall sensors. In the second, the combination of spinning-current Hall sensors and pickup coils achieves the same offset, with a resolution of 210 μT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> in a further extended bandwidth of 3 MHz, which is the widest bandwidth ever reported for a CMOS magnetic sensor.

Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of reactive oxygen species, such as superoxide anions produced by NAD(P)H oxidase, induces endothelial dysfunction. Because immunosuppressive drugs have been associated with increased reactive oxygen species production and endothelial dysfunction, we sought to elucidate the underlying mechanisms. Reactive oxygen species, release of superoxide anions, and NAD(P)H oxidase activity were studied in human umbilical vein endothelial cells and in polymorphonuclear neutrophils. Gp91ds-tat was used to specifically block NAD(P)H oxidase. Transcriptional activation of different subunits of NAD(P)H oxidase was assessed by real-time RT-PCR. Rac1 subunit translocation and activation were studied by membrane fractionation and pull-down assays. Calcineurin inhibitors significantly increased endothelial superoxide anions production because of NAD(P)H oxidase, whereas mycophenolate acid (MPA) blocked it. MPA also attenuated the respiratory burst induced by neutrophil NAD(P)H oxidase. Because transcriptional activation of NAD(P)H oxidase was not affected, but addition of guanosine restored endothelial superoxide anions formation after MPA treatment, we speculate that the inhibitory effect of MPA was mediated by depletion of cellular guanosine triphosphate content. This prevented activation of Rac1 and, thus, of endothelial NAD(P)H oxidase. Because all heart transplant recipients are at risk for cardiac allograft vasculopathy development, these differential effects of immunosuppressants on endothelial oxidative stress should be considered in the choice of immunosuppressive drugs.

This paper presents a CMOS image sensor with a pinned-photodiode 4T active-pixel design (APS) that uses a buried-channel source follower (BSF) as the in-pixel amplifier. A prototype of the image sensor has been fabricated in a 0.18mum CMOS process. Measurements show that compared to a regular imager with a standard nMOS transistor surface-mode source follower (SSF), the new pixel structure reduces dark random noise by more than 50% and improves output swing by almost 100%.