Institut National des Langues et Civilisations Orientales

Describes the basic techniques in the training of language translation and interpretation. Chapters in this text describe: communication and quality; comprehension; knowledge acquisition; and coping tactics.

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.

Significance Given its size and geographical extension, Sino-Tibetan is of the highest importance for understanding the prehistory of East Asia, and of neighboring language families. Based on a dataset of 50 Sino-Tibetan languages, we infer phylogenies that date the origin of the language family to around 7200 B.P., linking the origin of the language family with the late Cishan and the early Yangshao cultures.

The human settlement of the Pacific Islands represents one of the most recent major migration events of mankind. Polynesians originated in Asia according to linguistic evidence or in Melanesia according to archaeological evidence. To shed light on the genetic origins of Polynesians, we investigated over 400 Polynesians from 8 island groups, in comparison with over 900 individuals from potential parental populations of Melanesia, Southeast and East Asia, and Australia, by means of Y chromosome (NRY) and mitochondrial DNA (mtDNA) markers. Overall, we classified 94.1% of Polynesian Y chromosomes and 99.8% of Polynesian mtDNAs as of either Melanesian (NRY-DNA: 65.8%, mtDNA: 6%) or Asian (NRY-DNA: 28.3%, mtDNA: 93.8%) origin, suggesting a dual genetic origin of Polynesians in agreement with the "Slow Boat" hypothesis. Our data suggest a pronounced admixture bias in Polynesians toward more Melanesian men than women, perhaps as a result of matrilocal residence in the ancestral Polynesian society. Although dating methods are consistent with somewhat similar entries of NRY/mtDNA haplogroups into Polynesia, haplotype sharing suggests an earlier appearance of Melanesian haplogroups than those from Asia. Surprisingly, we identified gradients in the frequency distribution of some NRY/mtDNA haplogroups across Polynesia and a gradual west-to-east decrease of overall NRY/mtDNA diversity, not only providing evidence for a west-to-east direction of Polynesian settlements but also suggesting that Pacific voyaging was regular rather than haphazard. We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji.

Building upon the model of Semantic Maps (Haspelmath 2003), which typologists have designed mainly for grammatical semantics, this chapter discusses methodological issues for a model in lexical typology. By breaking up polysemous lexemes of various languages into their semantic “atoms” or senses, one defines an etic grid against which cross-linguistic comparison can be undertaken. Languages differ as to which senses they colexify , i.e., lexify identically. But while each polysemous lexeme as a whole is language-specific, individual pairings of colexified senses can be compared across languages. Our model, understood as an empirical, atomistic approach to lexical typology, is finally exemplified with the rich polysemies associated with the notion “breathe”. Intertwined together, they compose a single, universal network of potential semantic extensions.

Arabic is recognised as the 4th most used language of the Internet. Arabic has three main varieties: (1) classical Arabic (CA), (2) Modern Standard Arabic (MSA), (3) Arabic Dialect (AD). MSA and AD could be written either in Arabic or in Roman script (Arabizi), which corresponds to Arabic written with Latin letters, numerals and punctuation. Due to the complexity of this language and the number of corresponding challenges for NLP, many surveys have been conducted, in order to synthesise the work done on Arabic. However these surveys principally focus on two varieties of Arabic (MSA and AD, written in Arabic letters only), they are slightly old (no such survey since 2015) and therefore do not cover recent resources and tools. To bridge the gap, we propose a survey focusing on 90 recent research papers (74% of which were published after 2015). Our study presents and classifies the work done on the three varieties of Arabic, by concentrating on both Arabic and Arabizi, and associates each work to its publicly available resources whenever available.

Adhesive capsulitis presents clinically as limited, active and passive range of motion caused by the formation of adhesions of the glenohumeral joint capsule. Radiographically, it is thickening of the capsule and rotator interval. The pathology of the disease, and its classification, relates to inflammation and formation of extensive scar tissue. Risk factors include diabetes, hyperthyroidism, and previous cervical spine surgery. Nonsurgical management includes physical therapy, corticosteroid injections, extracorporeal shock wave therapy, calcitonin, ultrasonography-guided hydrodissection, and hyaluronic acid injections. Most patients will see complete resolution of symptoms with nonsurgical management, and there appears to be a role of early corticosteroid injection in shortening the overall duration of symptoms. Surgical intervention, including manipulation under anesthesia, arthroscopic capsular release both limited and circumferential, and the authors' technique are described in this article. Complications include fracture, glenoid and labral injuries, neurapraxia, and rotator cuff pathology. Postoperative care should always include early physical therapy.

The Torres and Banks Islands, two small archipelagos of northern Vanuatu, are home to 9400 inhabitants and to 17 distinct languages. With an average of 550 speakers per language, this region constitutes an extreme case of the linguistic fragmentation which is typically observed throughout Melanesia. This study presents the linguistic diversity of that area, examines its social underpinnings and outlines its historical dynamics. These islands form an integrated network where a variety of social forces interact, sometimes in conflicting ways. A long lasting bias toward cultural differentiation of local communities has led historically to the linguistic mosaic observable today. This traditional fostering of diversity was correlated with a principle of egalitarian multilingualism. But while these ancient social attitudes have survived to this day, the linguistic diversity of northern Vanuatu has already begun to erode, due to various recent social changes. These changes have reshaped the language ecology of the region and already resulted in the partial loss of earlier linguistic diversity. While northern Vanuatu is still linguistically diverse today, the increased imbalance of power among languages potentially makes the weaker varieties vulnerable in the decades to come.

The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt ThinPrep liquid Pap) in a screening setting (French APTIMA screening evaluation [FASE] study). Women (N = 5,006) aged 20-65 were screened by gynecologists in 17 private practices in Paris, France. One cervical specimen was collected and tested with LBC, AHPV and HC2 assays. Women were referred to colposcopy if they were ASC-US+ in LBC or HPV positive in either HPV assay. To control for verification bias, a random group (14%) with normal LBC and dually HPV negative tests underwent colposcopy. Data from 4,429 women were analyzed. Sensitivity, specificity and predictive values were calculated for the three tests. AHPV and HC2 were highly sensitive for CIN2+ (92.0% and 96.7%) and CIN3+ (95.7% and 95.3%) detection and much more sensitive than LBC (69.1% for CIN2+ and 73.3% for CIN3+). Specificity of AHPV was higher than that of HC2, but similar to that of LBC (p < 0.001). Combining LBC with either HPV test slightly increased sensitivity but compromised specificity. AHPV assay is both specific and sensitive for the detection of high-grade precancerous lesions and may be considered as an option for routine cervical cancer screening for women over 20 years of age.

BACKGROUND: This study aimed to examine the major reasons for total hip arthroplasty (THA) failure and temporal patterns in THA revisions. METHODS: A retrospective chart review was conducted on 535 revisions performed on 444 THAs from January 2010 to May 2019 at our institution. RESULTS: The average time to revision THA was 8.51 ± 8.38 years, with 136 cases (30.9%) occurring within 2 years after primary THA. The major mechanisms of failure that resulted in revision surgery were mechanical failure (162, 36.5%), metallosis (95, 21.4%), dislocation or instability (65, 14.6%), periprosthetic fracture (46, 10.4%), infection (44, 9.9%), hematoma or poor wound healing (15, 3.4%), and pain or other (17, 3.8%). CONCLUSION: Based on our institutional experience over the past decade, mechanical failure without dislocation, metallosis, dislocation, periprosthetic fracture, and infection are typical reasons patients present for primary THA revision. Revisions within 2 years after primary THA are more likely to be the result of infection and periprosthetic fracture. Mechanical failure is the most common reason for revision THA overall, and mechanical failure and metallosis are more likely to be the reason revision is necessary 2 or more years after primary THA.

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When evaluating patients with irreparable rotator cuff tears, orthopaedic surgeons have an increasingly wide array of surgical options, including both established techniques and emerging technologies. However, significant variability exists in the clinical evaluation and surgical indications in this subset, and definitions for pseudoparalysis and tear irreparability are inconsistent. In older patients with symptomatic rotator cuff arthropathy and relatively sedentary demands, the reverse total shoulder arthroplasty has been established as the preferred treatment option, producing reliable improvements in both pain and function. In younger patients without glenohumeral arthritis or pseudoparalysis, joint-preserving options are preferred, with recent literature highlighting alternative options including partial repair, bridging or interpositional graft placement, tendon transfers (ie, latissimus, trapezius, and pectoralis major), superior capsular reconstruction, and subacromial spacer placement. In this review article, we address the topic of irreparable rotator cuff tears, emphasizing the workup, indications for various treatment options, and clinical outcomes.

While global patterns of human genetic diversity are increasingly well characterized, the diversity of human languages remains less systematically described. Here, we outline the Grambank database. With over 400,000 data points and 2400 languages, Grambank is the largest comparative grammatical database available. The comprehensiveness of Grambank allows us to quantify the relative effects of genealogical inheritance and geographic proximity on the structural diversity of the world's languages, evaluate constraints on linguistic diversity, and identify the world's most unusual languages. An analysis of the consequences of language loss reveals that the reduction in diversity will be strikingly uneven across the major linguistic regions of the world. Without sustained efforts to document and revitalize endangered languages, our linguistic window into human history, cognition, and culture will be seriously fragmented.

The involvement of superoxide anion (O2o-) in human sperm capacitation and/or acrosome reaction was investigated. Addition of superoxide dismutase (SOD) to the medium at the beginning of the capacitation process or 15 min before induction of the acrosome reaction, decreased the level of ionophore-induced acrosome reaction. Hyperactivation was unaffected by the presence of SOD during the capacitation process. Addition of calcium ionophore to the sperm suspension increased production of O2o- by the spermatozoa by four to five-fold and induced the acrosome reaction. In the presence of SOD, superoxide anion could not be detected in the medium and the rate of induced-acrosome reaction was decreased greatly. The presence of an inhibitor of protein kinase C inhibited the production of O2o- in the medium and reduced the induced-acrosome reaction. The production of O2o- and the acrosome reaction were also increased by exposure of spermatozoa to 12-myristate 13-acetate phorbol ester, a specific activator of protein kinase C. While the level of spontaneous acrosome reaction was not increased by the direct addition of O2o- to the medium, its presence induced the release of unesterified fatty acids from membrane phospholipids. These findings suggest that the production of O2o- by spermatozoa could be involved in the ionophore-induced acrosome reaction, possibly through the de-esterification of membrane phospholipids. However, this production of superoxide anion is not sufficient on its own to induce the acrosome reaction.

Abstract Very little actual scientific research has been carried out in I/T to date, essentially because of the lack of scientific background among I/T investigators. Major problems are found in the sampling procedures, materials, experimental conditions and tasks, quantification procedures and conclusion-drawing logic. In order to foster I/T research, methodological research training could be given to investigators, and interdisciplinary contacts and networking should be promoted. The input of I/T practitioners to I/T research can be valuable in spite of their lack of training provided they use simple methods and are supervised appropriately. Non I/T practitioners should work with practitioners.

Thousands of single-copy internal eliminated sequences (IESs) are excised from the germ line genome of ciliates during development of the polygenomic somatic macronucleus, following sexual events. Paramecium IESs are short, noncoding elements that frequently interrupt coding sequences. No absolutely conserved sequence element, other than flanking 5'-TA-3' direct repeats, has been identified among sequenced IESs; the mechanisms of their specific recognition and precise elimination are unknown. Previous work has revealed the existence of an epigenetic control of excision. It was shown that the presence of one IES in the vegetative macronucleus results in a specific inhibition of the excision of the same element during the development of a new macronucleus, in the following sexual generation. We have assessed the generality and sequence specificity of this transnuclear maternal control by studying the effects of macronuclear transformation with 13 different IESs. We show that at least five of them can be maintained in the new macronuclear genome; sequence specificity is complete both between genes and between different IESs in the same gene. In all cases, the degree of excision inhibition correlates with the copy number of the maternal IES, but each IES shows a characteristic inhibition efficiency. Short internal IES-like segments were found to be excised from two of the IESs when excision between normal boundaries was inhibited. Available data suggest that the sequence specificity of these maternal effects is mediated by pairing interactions between homologous nucleic acids.

An inquiry into the emergence of non-canonical subjects in Hindi may be a first step in evaluating the importance of semantic alignments in the language. The modern data display a cline of subject properties depending on the case and semantic role (Section 1). A brief account of the ancient data in Sanskrit (Section 2) shows that the most innovative development was that of experiencer subjects, which emerged in early NIA along with inefficient and involuntary actors (Section 3). This rise was related to global systemic changes in the language, particularly the development of new case markers (Section 4). The last section examines the main factors responsible for this shift, particularly re-analysis, usage and speaker’s viewpoint, lexical renewal and contact.

INTRODUCTION: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up. METHODS: A total of 51 patients (55 legs) with TFA were included in a prospective study. Complications, success rate, and PRO measures were followed for 5 years. RESULTS: The cumulative fixture survival rate at 5 years was 92%, and the revision-free survival rate was 45%. Thirty-four patients had 70 superficial infections. Eleven patients had 14 deep infections. Fifteen patients had mechanical complications. Four fixtures were removed (ie, one deep infection and three loosening). PRO measures showed significant improvements including more use of the prosthesis, better mobility, fewer issues, and improved physical health-related quality of life (all P < 0.0001) compared with baseline. CONCLUSION: Individuals with TFA at 5-year follow-up had significant improvement in PRO measures, but increases in deep infections and mechanical complications are concerning.

The influence of succinate treatment on Zn toxicity was investigated using plant growth and mineral uptake as stress indicators. Pea plants (Pisum sativum L., cv. Citrine) were treated with various Zn concentrations (0.67 to 700 muM Zn) in the presence and absence of 0.2 mM Na-succinate. Plants pre-treated with succinate and then exposed to Zn exhibited higher dry root, stem and leaf weight than the plants treated with Zn alone. An increase in Zn supply resulted in a decrease in the concentrations of Ca, Mg, P in the roots and an increase of Ca and N levels in the stems and leaves. The amount of Zn in the roots, stems and leaves increased with greater Zn rates. The succinate treatment increased P in the roots but did not affect the Ca, N and Mg contents in Zn-treated plants. Most of the Zn taken up was retained in the roots after succinate treatment. The ameliorative effect of succinate on plant growth could be due to a lower Zn translocation in the leaves and stems and increased Zn accumulation in the roots. Lower Zn translocation in aboveground parts seemed to result from Zn complexing by organic anion in the roots. This probably caused less Zn transport to the stems and leaves and suggested that succinate has potential for complexing with Zn and may play a role in tolerance to high Zn levels.

Il s'agit dans cet article de faire une étude sémantique et morphologique du diminutif dans le dialecte arabe de Mauritanie. Les différents emplois de cette dérivation sont recensés et classés selon la fonction dénotative et/ou connotative du signifié. La prise en considération de différents types de discours - en particulier le discours poétique - fait ressortir la nature énonciative du diminutif et son rôle dans la stratégie expressive du locuteur. La seconde partie traite des différentes formes diminutives, tant nominales que verbales. Il en est d'abord fait l'inventaire dans le dialecte hassâniyya de Mauritanie. Des considérations comparatives permettent ensuite de situer le hassâniyya par rapport aux dialectes maghrébins.